Letrozole

Letrozole

Structural formula of Letrozole

Letrozole is an antineoplastic medication used as a tablet to treat some types of advanced breast cancer in postmenopausal women.

It is not to be used in pregnancy, breastfeeding or children, and used with caution in kidney and liver disease. Do not take it if still having menstrual periods.

Common side effects may include:

  • headache,
  • nausea,
  • diarrhoea,
  • swelling of hands and feet,
  • tiredness,
  • hot flushes,
  • hair thinning,
  • rash,
  • vaginal discharge.

Unusual side effects may include:

  • weight change,
  • muscle pain,
  • vaginal bleeding,
  • sweating,
  • dizziness,
  • tiredness,
  • increased appetite,
  • joint pain,
  • urgent desire to pass urine,
  • acne,
  • breast enlargement.

A blood clot in a vein (thrombosis) is a rare but severe complication. It interacts with tamoxifen. Letrozole was introduced in 1998 for treatment of severe relapses of some types of breast cancer.

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