Mazindol must be used in conjunction with a diet and counselling. Half to one tablet is taken one hour before one to three meals a day.
It is not for use in pregnancy, breastfeeding or children under 14 years. Mazindol must be used with caution in diabetes, psychiatric disturbances, drug dependence, heart disease and the elderly, and should not be used at all if suffering from glaucoma, agitation, anxiety, uncontrolled high blood pressure, heart disease, drug abuse, stomach ulcer, prostate gland enlargement, severe liver or kidney disease. The blood pressure of users should be checked regularly, and it is not for long-term use.
Common side effects can include a dry mouth, constipation, nervousness, disturbed sleep and irritability. Less commonly dizziness, tremor, headache, weakness, depression, rapid heart rate, irregular heartbeat, high blood pressure, diarrhoea, bad taste, nausea, vomiting, rash, sweating, difficulty in passing urine and impotence occur.
Mazindol interacts with MAOI, hypoglycaemics, anaesthetics, insulin, thyroxine, stimulants, amantadine, antihypertensives, alcohol and caffeine. It may cause dependence, and rarely may cause addiction.