Oestrone is a female sex hormone used only in combination with other forms of oestrogen for hormone replacement therapy in the menopause. It is not designed to be used in pregnancy, breastfeeding or children, but accidental usage in these situations is unlikely to be harmful. Use it with caution in epilepsy, migraine, heart failure, high blood pressure, kidney disease, diabetes, porphyria or uterine disease.
Do not take oestrone if suffering from liver disease, breast or genital cancer or a history of blood clots.
Side effects may include abnormal uterine bleeding, vaginal thrush, nausea, fluid retention, weight gain and breast tenderness. Unusual side effects may include a rash, blurred vision, vomiting, bloating, intestinal cramps, pigmentation of skin on face, blood clots, calf or chest pain and yellow skin (jaundice). Smoking increases the risk of serious side effects.
Interactions may occur with other sex hormones, rifampicin and the herbs saw palmetto, alfalfa, dong quai, ginseng, liquorice and red clover. Vomiting and abnormal vaginal bleeding are the only likely effects of an overdose.