Paget’s Disease – Hydroxy-proline/Creatinine Ratio

The ratio between the chemicals hydroxyproline and creatinine in blood can be measured. The normal level is less than 0.02.

High levels may indicate:

  • Paget’s disease of bone,
  • hyperparathyroidism (over active parathyroid gland),
  • osteomalacia (bone disease),
  • hyperthyroidism (over active thyroid gland),
  • osteoporosis after the menopause,
  • kidney failure
  • a severe fracture.

The ratio is a measure of the bone breakdown rate and calcium loss.

Calcium supplementation lowers the ratio after menopause.

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