The ratio between the chemicals hydroxyproline and creatinine in blood can be measured. The normal level is less than 0.02.
High levels may indicate:
- Paget’s disease of bone,
- hyperparathyroidism (over active parathyroid gland),
- osteomalacia (bone disease),
- hyperthyroidism (over active thyroid gland),
- osteoporosis after the menopause,
- kidney failure
- a severe fracture.
The ratio is a measure of the bone breakdown rate and calcium loss.
Calcium supplementation lowers the ratio after menopause.