Piperazine oestrone sulfate (Ogen) is an oestrogen (female sex hormone) used for hormone replacement therapy (HRT) in menopause and to ease the discomfort of a dry vagina after menopause.
These tablets are not designed to be used in pregnancy, breastfeeding or children, but accidental usage in these situations is unlikely to be harmful.
It should also not be used in liver disease, breast or genital cancer, blood clots or history thereof, otosclerosis, breast cancer, genital cancer, undiagnosed vaginal bleeding or sickle cell anaemia.
Use with caution in epilepsy, migraine, heart failure, high blood pressure, kidney disease, diabetes, porphyria or uterine disease (eg. fibroids).
A pre-treatment gynaecological and general examination is essential and piperazine oestrone should be used in conjunction with a progestogen if still menstruating.
Side effects may include abnormal uterine bleeding, vaginal thrush, nausea, fluid retention, weight gain and breast tenderness. Unusual side effects may include a rash, blurred vision, vomiting, bloating, intestinal cramps, pigmentation of skin on face and rarely blood clots, calf or chest pain and yellow skin (jaundice).
Piperazine oestrone may interact with other sex hormones, warfarin, anticonvulsants (treat epilepsy), hypoglycaemics (treat diabetes), pethidine, theophylline, beta-blockers, phenothiazines, thyroxine, tricyclic antidepressants, cyclosporin, bromocriptine and caffeine. Smoking increases the risk of serious side effects.