The amount of pregnancy-associated plasma protein-A (PAPP-A) can be measured in the blood of a pregnant woman. It is normally performed in conjunction with a blood test for human chorionic gonadotrophin (HCG) and a nuchal translucency ultrasound scan between 10 and 14 weeks of pregnancy in more mature mothers. The normal range of values for this test varies with the pregnancy duration
A low level of PAPP-A is associated with an increased risk of Down syndrome, stillbirth, pre-eclampsia, other chromosomal abnormalities and intrauterine growth retardation. In non-pregnant patients, a high level has been found to be associated with heart disease such as the acute coronary syndrome
PAPP-A is normally involved in wound healing.