It was released in 1999 to assist women who are unable to tolerate normal postmenopausal hormone replacement therapy.
It must never be used in pregnancy (causes deformities of foetus), breastfeeding, children, if still menstruating, with a medical history of blood clots or if male. It is for use in postmenopausal women only. Use with caution in liver disease and high triglyceride level. Any abnormal uterine bleeding must be diagnosed before raloxifene is used.
Side effects may include hot flushes, leg cramps, sinus congestion and rarely blood clots. It may interact with oestrogen supplements, cholestyramine, ampicillin and warfarin.