Sertoli Cell Tumour
Sertoli cells develop in the testes, but may also be found in small numbers in the ovaries. A Sertoli cell tumour may be benign (harmless) or malignant (cancerous).
These tumours secrete excessive amounts of testosterone, and in women cause symptoms of masculinisation such as cessation of menstruation, acne, facial hair growth, a deep voice, increased muscle development and enlargement of the clitoris. The symptoms in males are a subtle increase in masculinity.
The diagnosis is confirmed by blood tests that show high levels of testosterone and an ultrasound or CT scan of the ovaries or testes.
Treatment involves surgically removing the affected ovary or testicle, followed by chemotherapy if the tumour is malignant.